Glycochenodeoxycholic acid-d7 (sodium)

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Products Details

Product Description

– Glycochenodeoxycholic acid-d7 (sodium) is the deuterium labeled Glycochenodeoxycholic acid (sodium salt). Glycochenodeoxycholic acid sodium salt (Chenodeoxycholylglycine sodium salt) is a bile acid formed in the liver from chenodeoxycholate and glycine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. Glycochenodeoxycholic acid sodium salt (Chenodeoxycholylglycine sodium salt) induces hepatocyte apoptosis[1][2].

Web ID

– HY-N2334AS

Shipping

– Room temperature

Molecular Formula

– C26H35D7NNaO5

References

– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Liang S, et al. Effect of quercetin 7-rhamnoside on glycochenodeoxycholic acid-induced L-02 human normal livercell apoptosis. Int J Mol Med. 2013 Aug;32(2):323-30.|[3]Gonzalez B, et al. Glycochenodeoxycholic acid (GCDC) induced hepatocyte apoptosis is associated with early modulation of intracellular PKC activity. Mol Cell Biochem. 2000 Apr;207(1-2):19-27.

Molecular Weight

– 478.65

SMILES

– C[C@@]12[C@](CC[C@]2([H])[C@H](C)C([2H])([2H])CC(NCC(O[Na])=O)=O)([H])[C@@]3([H])[C@]([C@@]4([C@](C([2H])([2H])[C@@](O)([2H])C([2H])([2H])C4)([H])C[C@H]3O)C)([H])CC1

Clinical Information

– No Development Reported

Research Area

– Cancer

Solubility

– 10 mM in DMSO

Target

– Apoptosis;Endogenous Metabolite;Isotope-Labeled Compounds

Pathway

– Apoptosis;Metabolic Enzyme/Protease;Others

Product type

– Isotope-Labeled Compounds

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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