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Products Details
Product Description
– Glycochenodeoxycholic acid-d7 (sodium) is the deuterium labeled Glycochenodeoxycholic acid (sodium salt). Glycochenodeoxycholic acid sodium salt (Chenodeoxycholylglycine sodium salt) is a bile acid formed in the liver from chenodeoxycholate and glycine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. Glycochenodeoxycholic acid sodium salt (Chenodeoxycholylglycine sodium salt) induces hepatocyte apoptosis[1][2].
Web ID
– HY-N2334AS
Shipping
– Room temperature
Molecular Formula
– C26H35D7NNaO5
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Liang S, et al. Effect of quercetin 7-rhamnoside on glycochenodeoxycholic acid-induced L-02 human normal livercell apoptosis. Int J Mol Med. 2013 Aug;32(2):323-30.|[3]Gonzalez B, et al. Glycochenodeoxycholic acid (GCDC) induced hepatocyte apoptosis is associated with early modulation of intracellular PKC activity. Mol Cell Biochem. 2000 Apr;207(1-2):19-27.
Molecular Weight
– 478.65
SMILES
– C[C@@]12[C@](CC[C@]2([H])[C@H](C)C([2H])([2H])CC(NCC(O[Na])=O)=O)([H])[C@@]3([H])[C@]([C@@]4([C@](C([2H])([2H])[C@@](O)([2H])C([2H])([2H])C4)([H])C[C@H]3O)C)([H])CC1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Endogenous Metabolite;Isotope-Labeled Compounds
Pathway
– Apoptosis;Metabolic Enzyme/Protease;Others
Product type
– Isotope-Labeled Compounds
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