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Products Details
Product Description
– Gly-Cyclopropane-Exatecan involves in the synthesis of anti-B7-H4 ADC, containing Exatecan (HY-13631), a DNA Topoisomerase I inhibitor. Gly-Cyclopropane-Exatecan participated in the formation of the ADC hu2F7-Exatecan (compound 34), which showed antitumor activity in vivo and in vitro[1].
Web ID
– HY-148696A
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C32H34FN5O7
References
– [1]Hua Haiqing, et al. Anti-b7-h4 antibody-drug conjugate and medicinal use thereof: World Intellectual Property Organization, WO2020244657. 2020-12-10.
CAS Number
– 2414254-49-0
Molecular Weight
– 619.64
SMILES
– NCC(NCOC(C1CC1)C(N[C@@H]2C3=C4C(C(N5C4)=CC([C@](O)(C(OC6)=O)CC)=C6C5=O)=NC7=CC(F)=C(C)C(CC2)=C73)=O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– ADC Cytotoxin;Topoisomerase
Isoform
– Topo I
Pathway
– Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage
Product type
– Reference compound
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