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Glucocorticoid receptor modulator 1
$320 – $2,600
Products Details
Product Description
– Glucocorticoid receptor modulator 1 is a highly potent and orally active non-steroidal selective glucocorticoid receptor modulator with an IC50 value of 9 nM and 130 nM for NF-κB and AP-1, respectively. Glucocorticoid receptor modulator 1 can effectively reduce the expression of inflammatory factors IL-6, IL-1β, TNF-α, also can relieve dermatitis in mice[1].
Web ID
– HY-151876
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture and light)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C24H23ClN2O4S
References
– [1]Li D, Hou T, et al. Discovery and Optimization of N-Acyl-6-sulfonamide-tetrahydroquinoline Derivatives as Novel Non-Steroidal Selective Glucocorticoid Receptor Modulators. J Med Chem. 2022 Nov 18.
CAS Number
– 2868357-11-1
Molecular Weight
– 470.97
Compound Purity
– 99.79
SMILES
– COC1=C(C=C(C(C)=C1)Cl)S(=O)(NC2=CC=C3C(CCCN3C(C4=CC=CC=C4)=O)=C2)=O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– DMSO : 100 mg/mL (ultrasonic)
Target
– AP-1;Glucocorticoid Receptor;NF-κB
Pathway
– Immunology/Inflammation;NF-κB;Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
