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Products Details
Product Description
– Glucocorticoid receptor-IN-2 (Compound WX019) is a selective glucocorticoid receptor (GR) modulator with anti-inflammatory effect. Glucocorticoid receptor-IN-2 exhibits very good transcriptional repressive activity with an IC50 of 0.171 nM against hMMP1, and comparable transcriptional activation activity with an EC50 of 0.94 nM against MMTV[1].
Web ID
– HY-142942
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C25H20F4N6O2
References
– [1]Sheng Su, et al. Benzopyrazole compound. WO2021136429.
CAS Number
– 2664932-65-2
Molecular Weight
– 512.46
SMILES
– CC(F)(F)C(N[C@@H](C)[C@@H](C1=CC(F)=CC(F)=C1)OC2=CC=C(N(C3=CN4C(C=C3)=NN=C4)N=C5)C5=C2)=O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Glucocorticoid Receptor;MMP
Pathway
– Immunology/Inflammation;Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
