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Products Details
Product Description
– GLS1 Inhibitor-6 (Compound 24y) is an orally active, potent and selective glutaminase 1 (GLS1) inhibitor (IC50=68 nM), shows 220-fold selectivity for GLS2. GLS1 Inhibitor-6 shows good anti-tumor activity, antitumor cell proliferation activity and induces apoptosis[1].
Web ID
– HY-151434
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C37H52N6O3S
References
– [1]Tao Yang, et al. Design, synthesis, and pharmacological evaluation of 2-(1-(1,3,4-thiadiazol-2-yl)piperidin-4-yl)ethan-1-ol analogs as novel glutaminase 1 inhibitors. Eur J Med Chem. 2022 Aug 19;243:114686.
Molecular Weight
– 660.91
SMILES
– O=C(NCC1CCN(CCCCCC)CC1)C2=CC=CC(COCCC3CCN(C4=NN=C(NC(CC5=CC=CC=C5)=O)S4)CC3)=C2
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Glutaminase
Pathway
– Apoptosis;Metabolic Enzyme/Protease
Product type
– Reference compound
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