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Products Details
Product Description
– GLPG-3221 is a potent, orally active corrector of CFTR (cystic fibrosis transmembrane conductance regulator), with an EC50 of 105 nM. GLPG-3221 can be uesd for the treatment of cystic fibrosis[1].
Web ID
– HY-133013
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C30H37F3N2O6
References
– [1]Scanio MJC, et al.Discovery of ABBV/GLPG-3221, a Potent Corrector of CFTR for the Treatment of Cystic Fibrosis.ACS Med Chem Lett. 2019 Oct 31;10(11):1543-1548.
CAS Number
– 2222264-64-2
Molecular Weight
– 578.62
SMILES
– O=C(O)[C@H]1N(C([C@@H]2CCCCO2)=O)[C@@H](C3=CC=CC=C3C)[C@@H](OCC4=CC(C(F)(F)F)=CN=C4OC)[C@@H]1C(C)(C)C
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– CFTR
Pathway
– Membrane Transporter/Ion Channel
Product type
– Reference compound
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