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Products Details
Product Description
– Givinostat (ITF-2357) hydrochloride is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively[1][2][3].
Web ID
– HY-14842A
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C24H28ClN3O4
Citations
– Cell Death Dis. 2020 Sep 15;11(9):753.|Acta Pharmacol Sin. 2021 Apr 13.|Cell Prolif. 2021 May 24;e13072.|Commun Biol. 2021 Oct 29;4(1):1235.|J Orthop Transl. 29 (2021) 106-112.|Neuroscience. 2021 Apr 13;S0306-4522(21)00185-8.|J Mol Med (Berl). 2019 Aug;97(8):1183-1193.
References
– [1]Li S, et al. Specific inhibition of histone deacetylase 8 reduces gene expression and production of proinflammatory cytokines in vitro and in vivo. J Biol Chem. 2015 Jan 23;290(4):2368-78.|[2]Wang YG, et al. Givinostat inhibition of hepatic stellate cell proliferation and protein acetylation. World J Gastroenterol. 2015 Jul 21;21(27):8326-39.|[3]Leoni F, et al. The histone deacetylase inhibitor ITF2357 reduces production of pro-inflammatory cytokines in vitro and systemic inflammation in vivo. Mol Med. 2005 Jan-Dec;11(1-12):1-15.
CAS Number
– 199657-29-9
Molecular Weight
– 457.95
SMILES
– O=C(OCC1=CC=C2C=C(CN(CC)CC)C=CC2=C1)NC3=CC=C(C(NO)=O)C=C3.[H]Cl
Clinical Information
– Phase 3
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– HDAC
Isoform
– HD1;HD2;HDAC1;HDAC10;HDAC11;HDAC2;HDAC3;HDAC4;HDAC5;HDAC6;HDAC7;HDAC8;HDAC9
Pathway
– Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
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