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Gilteritinib hemifumarate
$100 – $550
Products Details
Product Description
– Gilteritinib (ASP2215) hemifumarate is a potent and ATP-competitive FLT3/AXL inhibitor with IC50 of 0.29 nM/0.73 nM, respectively.
Web ID
– HY-12432A
Storage Temperature
– 4°C (Powder, stored under nitrogen)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C29H44N8O3 0.5C4H4O4
Citations
– Blood Cancer Discov. 2022 Mar 4;bloodcandisc.0163.2021.|Eur J Med Chem. 2022 Jul 5;237:114356.|Biomed Pharmacother. 2023 Jun 29;165:115066.|Blood Cancer J. 2022 Jan 11;12(1):5.|Cancer Cell Int. 2020 Jun 17;20:250.|Cancer Discov. 2023 Apr 3;CD-22-0411.|Cancers. 2020 Aug 19;12(9):2341.|Cancers. 2020 Jun 14;12(6):1574.|Department of Pharmacology & Toxicology. 2020 Jul.|Front Pharmacol. 2021 Mar 8;12:644342.|Haematologica. 2018 Nov;103(11):1862-1872.|J Oncol. 21 Sep 2021.|Mol Cancer Res. 2021 Oct 11.|Mol Pharmacol. April 5, 2022.|Sci Adv. 2022 Sep 16;8(37):eabp9005.|Sci Rep. 2021 Mar 11;11(1):5715.|Science. 2017 Dec 1;358(6367):eaan4368.|Separations. 2023 Apr 25, 10(5), 278.|Target Oncol. 2022 Oct 6.
References
– [1]ASP2215, a novel FLT3/AXL inhibitor: Preclinical evaluation in acute myeloid leukemia (AML). 2014 ASCO Annual Meeting.|[2]Mori M, et al. Gilteritinib, a FLT3/AXL inhibitor, shows antileukemic activity in mouse models of FLT3 mutated acute myeloid leukemia. Invest New Drugs. 2017 Oct;35(5):556-565.
CAS Number
– 1254053-84-3
Molecular Weight
– 610.75
Compound Purity
– 99.96
SMILES
– OC(/C=C/C(O)=O)=O.NC(C1=NC(CC)=C(NC2CCOCC2)N=C1NC3=CC(OC)=C(N4CCC(N5CCN(C)CC5)CC4)C=C3)=O.[0.5]
Clinical Information
– Launched
Research Area
– Cancer
Solubility
– DMSO : 6.67 mg/mL (ultrasonic;warming;heat to 70°C)|H2O : 2 mg/mL (ultrasonic)
Target
– FLT3;TAM Receptor
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
