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Genz-644282
$68 – $1,128
Products Details
Product Description
– Genz-644282 is a non-camptothecin topoisomerase I inhibitor, used for cancer research.
Web ID
– HY-16228
Storage Temperature
– 4°C (Powder, protect from light)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C22H21N3O5
References
– [1]Kurtzberg LS, et al. Genz-644282, a novel non-camptothecin topoisomerase I inhibitor for cancer treatment. Clin Cancer Res. 2011 May 1;17(9):2777-87.|[2]Houghton PJ, et al. Testing of the topoisomerase 1 inhibitor Genz-644282 by the pediatric preclinical testing program. Pediatr Blood Cancer. 2012 Feb;58(2):200-9.|[3]Sooryakumar D, et al. Molecular and cellular pharmacology of the novel noncamptothecin topoisomerase I inhibitor Genz-644282. Mol Cancer Ther. 2011 Aug;10(8):1490-9.
CAS Number
– 529488-28-6
Molecular Weight
– 407.42
Compound Purity
– 99.53
SMILES
– O=C1N(CCNC)C2=C(C=NC(C2=C3)=CC4=C3OCO4)C5=CC(OC)=C(OC)C=C15
Clinical Information
– Phase 1
Research Area
– Cancer
Solubility
– DMSO : 3.64 mg/mL (ultrasonic;warming;heat to 75°C)
Target
– Topoisomerase
Isoform
– Topo I
Pathway
– Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
