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Gemfibrozil
$66 – $119
Products Details
Product Description
– Gemfibrozil is an activator of PPAR-α, used as a lipid-lowering agent; Gemfibrozil is also a nonselective inhibitor of several P450 isoforms, with Ki values for CYP2C9, 2C19, 2C8, and 1A2 of 5.8, 24, 69, and 82 μM, respectively.
Web ID
– HY-B0258
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C15H22O3
References
– [1]Pahan K, et al. Gemfibrozil, a lipid-lowering drug, inhibits the induction of nitric-oxide synthase in human astrocytes. J Biol Chem. 2002 Nov 29;277(48):45984-91. Epub 2002 Sep 18.|[2]Almad A, et al. The PPAR alpha agonist gemfibrozil is an ineffective treatment for spinal cord injured mice. Exp Neurol. 2011 Dec;232(2):309-17.|[3]Wang JS, et al. Gemfibrozil inhibits CYP2C8-mediated cerivastatin metabolism in human liver microsomes. Drug Metab Dispos. 2002 Dec;30(12):1352-6.
CAS Number
– 25812-30-0
Molecular Weight
– 250.33
Compound Purity
– 99.91
SMILES
– O=C(O)C(C)(C)CCCOC1=CC(C)=CC=C1C
Clinical Information
– Launched
Research Area
– Metabolic Disease; Cardiovascular Disease; Cancer
Solubility
– DMSO : 100 mg/mL (ultrasonic)
Target
– Cytochrome P450;PPAR
Isoform
– CYP1;CYP2;PPARα
Pathway
– Cell Cycle/DNA Damage;Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
