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Products Details
Product Description
– GEM144 is a potent and orally active DNA polymerase α (POLA1) and HDAC 11 dual inhibitor. GEM144 induces acetylation of p53, activation of p21, G1/S cell cycle arrest, and apoptosis. GEM144 has significant antitumor activity in human orthotopic malignant pleural mesothelioma xenografts[1].
Web ID
– HY-143411
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C28H31NO5
References
– [1]Dallavalle S, et al. Antitumor activity of novel POLA1-HDAC11 dual inhibitors. Eur J Med Chem. 2022;228:113971.
CAS Number
– 2487526-28-1
Molecular Weight
– 461.55
SMILES
– ONC(C(C)OC1=C(C=C(C2=CC=C(C=C2)/C=C/C(O)=O)C=C1)C34CC5CC(CC(C5)C4)C3)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;DNA/RNA Synthesis;HDAC
Isoform
– HDAC11
Pathway
– Apoptosis;Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
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