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Products Details
Product Description
– Geissoschizoline ((+)-Geissoschizoline) is a potent inhibitor of human AChE/BChE, with IC50s of 20.40 µM and 10.21 µM, respectively. Geissoschizoline emerges as a possible multi-target prototype that can be very useful in studies of preventing neurodegeneration and restoring neurotransmission. Geissoschizoline aiso is a potent anti-inflammatory agent[1].
Web ID
– HY-N10429
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C19H26N2O
References
– [1]Josélia A Lima, et al. Geissoschizoline, a promising alkaloid for Alzheimer’s disease: Inhibition of human cholinesterases, anti-inflammatory effects and molecular docking. Bioorg Chem. 2020 Nov;104:104215.
CAS Number
– 18397-07-4
Molecular Weight
– 298.42
SMILES
– OC[C@@H]1[C@@]2([H])[C@]3(C4=CC=CC=C4N2)[C@@]5([H])N(C[C@H]([C@]1([H])C5)CC)CC3
Clinical Information
– No Development Reported
Research Area
– Neurological Disease; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Cholinesterase (ChE)
Isoform
– AChE;BChE
Pathway
– Neuronal Signaling
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
