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GDC-0425
$70 – $600
Products Details
Product Description
– GDC-0425 (RG-7602) is an orally available, highly selective small molecule ChK1 inhibitor. GDC-0425 can be used for the research of various malignancies[1][2].
Web ID
– HY-19926
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C18H19N5O
References
– [1]Xiao Ding, et al. A supported liquid extraction LC-MS/MS method for determination of concentrations of GDC-0425, a small molecule Checkpoint kinase 1 inhibitor, in human plasma. Biomed Chromatogr. 2016 Dec;30(12):1984-1991.|[2]Jeffrey R Infante, et al. Phase I Study of GDC-0425, a Checkpoint Kinase 1 Inhibitor, in Combination with Gemcitabine in Patients with Refractory Solid Tumors. Clin Cancer Res. 2017 May 15;23(10):2423-2432.|[3]Ho-June Lee, et al. Ras-MEK Signaling Mediates a Critical Chk1-Dependent DNA Damage Response in Cancer Cells. Mol Cancer Ther. 2017 Apr;16(4):694-704.
CAS Number
– 1200129-48-1
Molecular Weight
– 321.38
Compound Purity
– 99.48
SMILES
– N#CC1=NC=C2C(C3=CC=CN=C3N2)=C1OC4CCN(CC)CC4
Clinical Information
– Phase 1
Research Area
– Cancer
Solubility
– H2O : 25 mg/mL (ultrasonic;adjust pH to 3 with HCl)
Target
– Checkpoint Kinase (Chk)
Isoform
– Chk1
Pathway
– Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
