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GDC-0349
$145 – $1,043
Products Details
Product Description
– GDC-0349 is a potent and selective ATP-competitive mTOR inhibitor with a Ki of 3.8 nM. GDC-0349 inhibits of both mTORC1 and mTORC2 complexes.
Web ID
– HY-15248
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C24H32N6O3
References
– [1]Pei Z, et al. Discovery and Biological Profiling of Potent and Selective mTOR Inhibitor GDC-0349. ACS Med Chem Lett. 2012 Nov 29;4(1):103-7.
CAS Number
– 1207360-89-1
Molecular Weight
– 452.55
Compound Purity
– 98.42
SMILES
– O=C(NCC)NC(C=C1)=CC=C1C2=NC3=C(CCN(C4COC4)C3)C(N5[C@@H](C)COCC5)=N2
Clinical Information
– Phase 1
Research Area
– Cancer
Solubility
– DMSO : ≥ 100 mg/mL
Target
– Autophagy;mTOR
Isoform
– mTOR;mTORC1;mTORC2
Pathway
– Autophagy;PI3K/Akt/mTOR
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
