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Products Details
Product Description
– Ganoderic acid T1 is a deacetylated derivative of Ganoderic acid T. Ganoderic acid T1 attenuates antioxidant defense system and induces apoptosis of cancer cells. Ganoderic acid T1 decreases mitochondrial membrane potential and activates caspase-9 and caspase-3, to trigger apoptosis. Ganoderic acid T1 also increases the generation of intracellular ROS to produce pro-oxidant activities and cytotoxicity[1].
Web ID
– HY-N11648
Shipping
– Room temperature
Molecular Formula
– C34H50O7
References
– [1]Liu RM, et al. Structurally related ganoderic acids induce apoptosis in human cervical cancer HeLa cells: Involvement of oxidative stress and antioxidant protective system. Chem Biol Interact. 2015 Oct 5;240:134-44.
Molecular Weight
– 570.76
SMILES
– C[C@]12C3=CCC4C([C@H](OC(C)=O)CC[C@@]4(C3=CC[C@]1(C)C([C@@H]([C@H](C/C=C(C(O)=O)C)O)C)C[C@@H]2OC(C)=O)C)(C)C
Clinical Information
– No Development Reported
Research Area
– Cancer; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Caspase
Isoform
– Caspase 3;Caspase 9
Pathway
– Apoptosis
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
