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Gandotinib
$60 – $610
Products Details
Product Description
– Gandotinib (LY2784544) is a potent JAK2 inhibitor with IC50 of 3 nM. Gandotinib (LY2784544) also inhibits FLT3, FLT4, FGFR2, TYK2, and TRKB with IC50 of 4, 25, 32, 44, and 95 nM.
Web ID
– HY-13034
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C23H25ClFN7O
References
– [1]Ma L, et al. Discovery and characterization of LY2784544, a small-molecule tyrosine kinase inhibitor of JAK2V617F. Blood Cancer J. 2013, 3, e109.
CAS Number
– 1229236-86-5
Molecular Weight
– 469.94
Compound Purity
– 99.82
SMILES
– CC1=NNC(NC2=NN3C(C(CN4CCOCC4)=C2)=NC(C)=C3CC5=CC=C(C=C5F)Cl)=C1
Clinical Information
– Phase 2
Research Area
– Cancer
Solubility
– DMSO : ≥ 50 mg/mL
Target
– FGFR;FLT3;JAK;VEGFR
Isoform
– FGFR2;FGFR3;JAK2;JAK3;Tyk2;VEGFR2/KDR/Flk-1;VEGFR3/Flt-4
Pathway
– Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
