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Products Details
Product Description
– gamma-secretase modulator 5 (compound 22d) is a brain-penetrant gamma-secretase modulator (GSMs) that inhibits the production of the aggregated amyloid β-peptide Aβ42 with an IC50 value of 60 nM. gamma-secretase modulator 5 can be used in the study of Alzheimer’s disease[1].
Web ID
– HY-150050
Shipping
– Room temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C22H25N7OS
References
– [1]Kevin D Rynearson, et al. Design and synthesis of novel methoxypyridine-derived gamma-secretase modulators. Bioorg Med Chem. 2020 Nov 15;28(22):115734.
CAS Number
– 1353570-53-2
Molecular Weight
– 435.55
SMILES
– CC1=CN(C2=CC=C(C3=CSC(NC4=C5C(CCCC5)=NN4CC)=N3)N=C2OC)C=N1
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Amyloid-β
Pathway
– Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
