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Galidesivir
$200 – $960
Products Details
Product Description
– Galidesivir (BCX4430), an adenosine analog and a direct-acting antiviral agent, disrupts viral RNA-dependent RNA polymerase (RdRp) activity. Galidesivir is active in vitro against many RNA viral pathogens, including the filoviruses and emerging infectious agents such as MERS-CoV, SARS-CoV, and SARS-CoV-2. Galidesivir inhibits some negative-sense RNA viruses with EC50s ranging from ~3 to ~68 μM[1][2][3].
Web ID
– HY-18649A
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C11H15N5O3
Citations
– Antiviral Res. 2017 Mar 21;142:63-67.|Exp Ther Med. 2016 Sep;12(3):1812-1816. |Microorganisms. 2021 Mar 31;9(4):734.|Nucleic Acids Res. 2021 Jan 8;49(D1):D1113-D1121.|Virology. 2023 May 26.|Viruses. 2020 Jun 10;12(6):628.|Antimicrob Agents Chemother. 2019 Feb 26;63(3):e02093-18.|Antiviral Res. 2017 Mar 21;142:63-67.|Nucleic Acids Res. 2021 Jan 8;49(D1):D1113-D1121.
References
– [1]Elfiky AA, et al. ICN-1229, Remdesivir, PSI-7977, Galidesivir, and GS 1278 against SARS-CoV-2 RNA dependent RNA polymerase (RdRp): A molecular docking study. Life Sci. 2020 Mar 25:117592.|[2]Taylor R, et al. BCX4430 – A broad-spectrum antiviral adenosine nucleoside analog under development for the treatment of Ebola virus disease. J Infect Public Health. 2016;9(3):220-226.|[3]Warren TK, et al. Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430. Nature. 2014;508(7496):402-405.|[4]Julander JG, et al. BCX4430, a novel nucleoside analog, effectively treats yellow fever in a Hamster model. Antimicrob Agents Chemother. 2014;58(11):6607-6614.
CAS Number
– 249503-25-1
Molecular Weight
– 265.27
Compound Purity
– 99.29
SMILES
– O[C@H]1[C@H](C2=CNC3=C2N=CN=C3N)N[C@H](CO)[C@H]1O
Clinical Information
– Phase 1
Research Area
– Infection
Solubility
– H2O : 100 mg/mL (ultrasonic)
Target
– DNA/RNA Synthesis;Filovirus;SARS-CoV
Pathway
– Anti-infection;Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
