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Galicaftor
$610 – $5,000
Products Details
Product Description
– Galicaftor (ABBV-2222; GLPG-2222) is a potent and orally active cystic fibrosis transmembrane conductance regulator (CFTR) corrector. Galicaftor can be used for cystic fibrosis research[1].
Web ID
– HY-111111
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C28H21F4NO7
References
– [1]Xueqing Wang, et al. Discovery of 4-[(2R,4R)-4-({[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl}amino)-7-(difluoromethoxy)-3,4-dihydro-2H-chromen-2-yl]benzoic Acid (ABBV/GLPG-2222), a Potent Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Corrector for the Treatment of Cystic Fibrosis. J Med Chem. 2018 Feb 22;61(4):1436-1449.|[2]Ashvani K Singh, et al. Biological Characterization of F508delCFTR Protein Processing by the CFTR Corrector ABBV-2222/GLPG2222. J Pharmacol Exp Ther. 2020 Jan;372(1):107-118.
CAS Number
– 1918143-53-9
Molecular Weight
– 559.46
Compound Purity
– 98.93
SMILES
– O=C(O)C1=CC=C([C@H]2C[C@@H](NC(C3(C4=CC=C(OC(F)(F)O5)C5=C4)CC3)=O)C6=CC=C(OC(F)F)C=C6O2)C=C1
Clinical Information
– Phase 2
Research Area
– Inflammation/Immunology
Solubility
– DMSO : 50 mg/mL (ultrasonic)
Target
– CFTR
Pathway
– Membrane Transporter/Ion Channel
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
