FzM1

SKU HY-116553-1 mg Category Tags , ,

$60$720

Products Details

Product Description

– FzM1 is a negative allosteric modulator (NAM) of Frizzled receptor FZD4. FzM1 reduces WNT5A-dependent WNT responsive element (WRE) activity (log EC50inh=−6.2). FzM1 binds to an allosteric binding site located in intracellular loop 3 (ICL3) of FZD4 and alters the conformation of the receptor, ultimately inhibiting the WNT/β-catenin cascade[1].

Web ID

– HY-116553

Storage Temperature

– -20°C, 3 years (Powder)

Shipping

– Blue Ice

Applications

– Cancer-programmed cell death

Molecular Formula

– C21H16N2O2S

References

– [1]Gennaro Riccio, et al. A Negative Allosteric Modulator of WNT Receptor Frizzled 4 Switches into an Allosteric Agonist. Biochemistry. 2018 Feb 6;57(5):839-851.

CAS Number

– 1680196-54-6

Molecular Weight

– 360.43

Compound Purity

– 98.62

SMILES

– O=C(NC1=CC2=CC=CC=C2C=C1)NC3=CC(O)=CC(C4=CC=CS4)=C3

Clinical Information

– No Development Reported

Research Area

– Cancer

Solubility

– DMSO : 62.5 mg/mL (ultrasonic)

Target

– Wnt;β-catenin

Pathway

– Stem Cell/Wnt

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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