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Products Details
Product Description
– FY-21 is a selective inhibitor of LSD1 (IC50=340 nM), with anti-proliferation and anti-colony formation activities. FY-21 enhances p53 expression, down-regulates HOXA9 and MEIS1 expression. FY-21 also induces leukemia cell differentiation to exhibts antitumor activity[1].
Web ID
– HY-155526
Shipping
– Room temperature
Molecular Formula
– C17H15F3N2O6
References
– [1]Yang C, et al. Discovery of new tetrahydroisoquinolines as potent and selective LSD1 inhibitors for the treatment of MLL-rearranged leukemia. Eur J Med Chem. 2023 Sep 5;257:115516.
Molecular Weight
– 400.31
SMILES
– OC1=C(C=C2C(NCCC2=C1)C3=CC=C(C=C3)[N+]([O-])=O)O.FC(C(O)=O)(F)F
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Histone Demethylase
Pathway
– Epigenetics
Product type
– Reference compound
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