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Products Details
Product Description
– FXIa-IN-8 is a potent and selective FXIa inhibitor with an IC50 of 14.2 nM. FXIa-IN-8 shows antithrombotic activity without increasing the bleeding risk and obvious toxicitysup>[1].
Web ID
– HY-144658
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C31H29ClN8O5
References
– [1]Yao N, et al. Targeting the S2 Subsite Enables the Structure-Based Discovery of Novel Highly Selective Factor XIa Inhibitors. J Med Chem. 2022; 65(5):4318-4334.
CAS Number
– 2744293-04-5
Molecular Weight
– 629.07
SMILES
– ClC1=CC(/C=C/C(N[C@H](C(NC2=CC=C(C=C2)C(O)=O)=O)CC(N3CCN(CC3)C4=CC=CC=C4)=O)=O)=C(C=C1)N5C=NN=N5
Clinical Information
– No Development Reported
Research Area
– Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– Factor Xa
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
