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Products Details
Product Description
– Fulvene-5 is a potent NADPH oxidase 4 (NOX4) inhibitor with antioxidant properties. Fulvene-5 is a reactive oxygen species (ROS) modifying agent and a potent radioprotector. Fulvene-5 has antitumor activity[1][2][3].
Web ID
– HY-12803
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C26H18N2
References
– [1]Murley JS, et al. ROS modifiers and NOX4 affect the expression of the survivin-associated radio-adaptive response. Free Radic Biol Med. 2018 Aug 1;123:39-52.|[2]Bhandarkar SS, et al. Fulvene-5 potently inhibits NADPH oxidase 4 and blocks the growth of endothelial tumors in mice. J Clin Invest. 2009 Aug;119(8):2359-65.|[3]Weyemi U, et al. Inactivation of NADPH oxidases NOX4 and NOX5 protects human primary fibroblasts from ionizing radiation-induced DNA damage. Radiat Res. 2015 Mar;183(3):262-70.
CAS Number
– 1075723-01-1
Molecular Weight
– 358.43
SMILES
– C1(C/2=C3C=CC=C3)=CC=CC=C1NC2=C4NC(C=CC=C5)=C5C4=C6C=CC=C/6
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– NADPH Oxidase;Reactive Oxygen Species
Isoform
– NOX4
Pathway
– Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
Product type
– Reference compound
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