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Products Details
Product Description
– FTO-IN-10 (compound 7) is a potent human demethylase FTO (the fat mass and obesity-associated protein) inhibitor with an IC50 of 4.5 μM. FTO-IN-10 enters the FTO’s structural domain II binding pocket through hydrophobic and hydrogen bonding interactions. FTO-IN-10 induces DNA damage and autophagic cell death in A549 cells[1].
Web ID
– HY-156405
Shipping
– Room temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C22H20N4O3
References
– [1]Chao Ge, et al. Novel 1,8-Naphthalimide Derivatives As Antitumor Agents and Potent Demethylase Inhibitors. ACS Med. Chem. Lett. 2023.
Molecular Weight
– 388.42
SMILES
– O=C(NC1=CC2=CC=CC(C(N(CCN(C)C)C3=O)=O)=C2C3=C1)C4=NC=CC=C4
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– Autophagy;Fat Mass and Obesity-associated Protein (FTO)
Pathway
– Autophagy;Metabolic Enzyme/Protease
Product type
– Reference compound
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