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Products Details
Product Description
– FTI-277 is an inhibitor of farnesyl transferase (FTase); a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling. FTI-277 can inhibit hepatitis delta virus (HDV) infection.
Web ID
– HY-15872
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C22H29N3O3S2
Citations
– Fish Shellfish Immunol. 2019 Apr 3;89:281-289.|Oncotarget. 2017 Nov 22;8(65):109135-109150. |Mol Cell Proteomics. 2023 Jun 14;100593.
References
– [1]Cohen-Jonathan E, et al. The farnesyltransferase inhibitor FTI-277 suppresses the 24-kDa FGF2-induced radioresistance in HeLa cells expressing wild-type RAS. Radiat Res. 1999 Oct;152(4):404-11.|[2]Nakazawa H, et al. Role of protein farnesylation in burn-induced metabolic derangements and insulin resistance in mouse skeletal muscle. PLoS One. 2015 Jan 16;10(1):e0116633.|[3]Virtanen SS, et al. Inhibition of GGTase-I and FTase disrupts cytoskeletal organization of human PC-3 prostate cancer cells. Cell Biol Int. 2010 Aug;34(8):815-26.
CAS Number
– 170006-73-2
Molecular Weight
– 447.61
SMILES
– CSCC[C@@H](C(OC)=O)NC(C1=CC=C(NC[C@@H](N)CS)C=C1C2=CC=CC=C2)=O
Clinical Information
– No Development Reported
Research Area
– Cancer; Infection
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Farnesyl Transferase;Ras
Pathway
– Apoptosis;GPCR/G Protein;Metabolic Enzyme/Protease
Product type
– Reference compound
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