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Products Details
Product Description
– Frovatriptan-d3 (hydrochloride) is the deuterium labeled Frovatriptan[1]. Frovatriptan is a potent 5-HT1B//D receptor agonist and has the highest 5-HT1B potency in the triptan class. Frovatriptan is apparently cerebroselective. Frovatriptan is efficacious and even superior in some endpoints also when taken during the headache phase in migraine attacks with aura[2].
Web ID
– HY-B1658S
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C14H15D3ClN3O
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Stefan Evers, et al. Efficacy of frovatriptan as compared to other triptans in migraine with aura.
Molecular Weight
– 282.78
SMILES
– NC(C1=CC=C2NC(CC[C@H](C3)NC([2H])([2H])[2H])=C3C2=C1)=O.Cl
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– 5-HT Receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Isotope-Labeled Compounds
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
