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FR-167356
$559
Only 1000 item(s) left in stock.
Products Details
Product Description
– FR-167356 is a potent, orally active and selective vacuolar ATPase inhibitor with IC50 values of 170, 220, 370, and 1200 nM for osteoclast plasma membranes, macrophage microsomes, renal brush border membranes, and liver lysosomal membranes, respectively. FR-167356 inhibits bone resorption and ovariectomy-induced bone loss[1].
Web ID
– HY-123370
Shipping
– Room temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C19H17Cl2NO3
References
– [1]Nishisho T, et, al. The a3 isoform vacuolar type H⁺-ATPase promotes distant metastasis in the mouse B16 melanoma cells. Mol Cancer Res. 2011 Jul;9(7):845-55.|[2]Niikura K, et, al. A vacuolar ATPase inhibitor, FR167356, prevents bone resorption in ovariectomized rats with high potency and specificity: potential for clinical application. J Bone Miner Res. 2005 Sep;20(9):1579-88.
CAS Number
– 174185-16-1
Molecular Weight
– 378.25
SMILES
– O=C(NC1=C(OC(C)=C2C(C)(O)C)C2=CC=C1)C3=C(Cl)C=CC=C3Cl
Clinical Information
– No Development Reported
Research Area
– Cancer; Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– Proton Pump
Pathway
– Membrane Transporter/Ion Channel
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
