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Products Details
Product Description
– Fozivudine tidoxil (BM-211290) is an orally active thioether lipid-zidovudine (ZDV) conjugate with anti-HIV activity. Fozivudine tidoxil, a member of the NRTI family of agent, is incorporated into the newly synthesized strand of DNA during intracellular viral replication and irreversibly binds viral RT which disrupts viral reverse-transcription[1][2]. Fozivudine tidoxil is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
Web ID
– HY-126781
Shipping
– Room temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C35H64N5O8PS
References
– [1]Michelle M Miller, et al. Administration of Fozivudine Tidoxil as a Single-Agent Therapeutic During Acute Feline Immunodeficiency Virus Infection Does Not Alter Chronic Infection. Viruses. 2012 Jun;4(6):954-62.|[2]P M Girard, et al. Phase II Placebo-Controlled Trial of Fozivudine Tidoxil for HIV Infection: Pharmacokinetics, Tolerability, and Efficacy. J Acquir Immune Defic Syndr. 2000 Mar 1;23(3):227-35.
CAS Number
– 141790-23-0
Molecular Weight
– 745.95
SMILES
– O=C(NC1=O)N(C=C1C)[C@](C[C@@H]2N=[N+]=[N-])([H])O[C@@H]2CO[P](OCC(OCCCCCCCCCC)CSCCCCCCCCCCCC)(O)=O
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– DNA/RNA Synthesis;HIV
Isoform
– HIV
Pathway
– Anti-infection;Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
