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Products Details
Product Description
– FOY 251 free base, an anti-proteolytic active metabolite of Camostate (HY-13512), acts as a proteinase inhibitor[1][2]. FOY 25 free base inhibits SARS-CoV-2 infection in cells assay[3].
Web ID
– HY-19727
Shipping
– Room temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C16H15N3O4
References
– [1]Ai Maekawa, et al. Camostat Mesilate Inhibits Prostasin Activity and Reduces Blood Pressure and Renal Injury in Salt-Sensitive Hypertension. J Hypertens . 2009 Jan;27(1):181-9.|[2]Markus Hoffmann, et al. Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity. bioRxiv. 2020 Aug 5;2020.08.05.237651.|[3]K Beckh, et al. Elimination of the Low-Molecular Weight Proteinase Inhibitor Camostate (FOY 305) and Its Degradation Products by the Rat Liver. Res Exp Med (Berl). 1987;187(6):401-6.
CAS Number
– 71079-08-8
Molecular Weight
– 313.31
SMILES
– O=C(O)CC1=CC=C(OC(C2=CC=C(NC(N)=N)C=C2)=O)C=C1
Clinical Information
– No Development Reported
Research Area
– Infection; Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– SARS-CoV;Ser/Thr Protease
Pathway
– Anti-infection;Metabolic Enzyme/Protease
Product type
– Reference compound
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