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Fostamatinib (disodium hexahydrate)
$96 – $708
Products Details
Product Description
– Fostamatinib (R788) disodium hexahydrate is the oral proagent of the active compound R406[1]. R406 is an orally available and competitive Syk/FLT3 inhibitor with a Ki of 30 nM and an IC50 of 41 nM[2]. R406 also inhibits Lyn (IC50=63 nM) and Lck (IC50=37 nM)[3].
Web ID
– HY-13038B
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C23H36FN6Na2O15P
References
– [1]Sylvia Braselmann, et al. R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation. J Pharmacol Exp Ther. 2006 Dec;319(3):998-1008.|[2]Hoon-Suk Cha , et al. A novel spleen tyrosine kinase inhibitor blocks c-Jun N-terminal kinase-mediated gene expression in synoviocytes. J Pharmacol Exp Ther. 2006 May;317(2):571-8.|[3]Stephen P McAdoo, et al. Fostamatinib Disodium. Drugs Future. 2011;36(4):273.
CAS Number
– 914295-16-2
Molecular Weight
– 732.51
Compound Purity
– 99.73
SMILES
– COC1=CC(NC2=NC=C(C(NC3=NC(N4COP(O[Na])(O[Na])=O)=C(C=C3)OC(C)(C)C4=O)=N2)F)=CC(OC)=C1OC.O.O.O.O.O.O
Clinical Information
– Launched
Research Area
– Cancer; Inflammation/Immunology
Solubility
– DMSO : 25 mg/mL (ultrasonic)|H2O : 2 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– FLT3;Syk
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
