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Fosnetupitant (chloride monohydrochloride )
SKU
HY-133206A-1 mg
Category Reference compound
Tags Cancer, GPCR/G Protein;Neuronal Signaling, Neurokinin Receptor
$320 – $660
Products Details
Product Description
– Fosnetupitant chloride monohydrochloride (Pronetupitant chloride monohydrochloride) is an NK1 antagonist with pKi values of 9.5, 6.1 for human NK1 and NK3Â receptor, respectively. Fosnetupitant chloride monohydrochloride is a methylene phosphate prodrug of Netupitant[1].
Web ID
– HY-133206A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C31H37Cl2F6N4O5P
References
– [1]Ruzza C, et al. In vitro and in vivo pharmacological characterization of Pronetupitant, a prodrug of the neurokinin 1 receptor antagonist Netupitant. Peptides. 2015 Jul;69:26-32.
CAS Number
– 1643757-72-5
Molecular Weight
– 761.52
Compound Purity
– 99.70
SMILES
– O=C(C(C)(C)C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)N(C)C2=CN=C(N3CC[N+](COP(O)(O)=O)(CC3)C)C=C2C4=C(C)C=CC=C4.[H]Cl.[Cl-]
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Neurokinin Receptor
Isoform
– NK1;NK3
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
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