Fosnetupitant (chloride monohydrochloride )

$320$660

Products Details

Product Description

– Fosnetupitant chloride monohydrochloride (Pronetupitant chloride monohydrochloride) is an NK1 antagonist with pKi values of 9.5, 6.1 for human NK1 and NK3 receptor, respectively. Fosnetupitant chloride monohydrochloride is a methylene phosphate prodrug of Netupitant[1].

Web ID

– HY-133206A

Storage Temperature

– 4°C (Powder, sealed storage, away from moisture)

Shipping

– Room Temperature

Applications

– Cancer-programmed cell death

Molecular Formula

– C31H37Cl2F6N4O5P

References

– [1]Ruzza C, et al. In vitro and in vivo pharmacological characterization of Pronetupitant, a prodrug of the neurokinin 1 receptor antagonist Netupitant. Peptides. 2015 Jul;69:26-32.

CAS Number

– 1643757-72-5

Molecular Weight

– 761.52

Compound Purity

– 99.70

SMILES

– O=C(C(C)(C)C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)N(C)C2=CN=C(N3CC[N+](COP(O)(O)=O)(CC3)C)C=C2C4=C(C)C=CC=C4.[H]Cl.[Cl-]

Clinical Information

– No Development Reported

Research Area

– Cancer

Solubility

– 10 mM in DMSO

Target

– Neurokinin Receptor

Isoform

– NK1;NK3

Pathway

– GPCR/G Protein;Neuronal Signaling

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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