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Fosaprepitant

Products Details

Product Description

– Fosaprepitant (L-785298) is a proagent of Aprepitant (HY-10052). Fosaprepitant is a neurokinin-1 receptor antagonist, which is development for the prevention of chemotherapy-induced nausea and vomiting (CINV)[1].

Web ID

– HY-14407

Shipping

– Room temperature

Applications

– Metabolism-protein/nucleotide metabolism

Molecular Formula

– C23H22F7N4O6P

Citations

– Cancer Biol Ther. 2019;20(5):653-665.|New J Chem. 29th November 2021.

References

– [1]Pranav Prasoon, et al. Role of fosaprepitant, a neurokinin Type 1 receptor antagonist, in morphine-induced antinociception in rats. Indian J Pharmacol. 2016 Jul-Aug; 48(4): 394-398.

CAS Number

– 172673-20-0

Molecular Weight

– 614.41

SMILES

– O=C1N=C(CN2[C@@H](C3=CC=C(F)C=C3)[C@@H](O[C@H](C)C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)OCC2)NN1P(O)(O)=O

Clinical Information

– Launched

Research Area

– Neurological Disease; Endocrinology; Cancer

Solubility

– 10 mM in DMSO

Target

– Neurokinin Receptor

Pathway

– GPCR/G Protein;Neuronal Signaling

Product type

– Reference compound

Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.

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