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Forodesine (hydrochloride)
$55 – $510
Products Details
Product Description
– Forodesine hydrochloride (BCX-1777 hydrochloride) is a highly potent and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC50 values ranging from 0.48 to 1.57 nM for human, mouse, rat, monkey and dog PNP. Forodesine hydrochloride is a potent human lymphocyte proliferation inhibitor. Forodesine hydrochloride could induce apoptosis in leukemic cells by increasing the dGTP levels[1][2].
Web ID
– HY-16209
Storage Temperature
– -20°C (Powder, stored under nitrogen)
Shipping
– Blue Ice
Applications
– Cancer-programmed cell death
Molecular Formula
– C11H15ClN4O4
Citations
– bioRxiv. 2019 Oct. |Biosens Bioelectron. 2020 Dec 1;169:112616.|Cell Rep. 2020 May 12;31(6):107640.|Cell. 2019 Oct 31;179(4):864-879.e19.|J Biol Chem. 2022 May;298(5):101876.|Nat Metab. 2020 Jul;2(7):635-647.|Nucleic Acids Res. 2020 Sep 25;48(17):e101.|Int J Biol Sci. 2023; 19(3):772-788.|J Med Chem. 2023 May 3.|Nat Commun. 2017 Aug 14;8(1):241. |Plant J. 2023 Dec 4.
References
– [1] Bieghs L, et al. The effects of forodesine in murine and human multiple myeloma cells. Adv Hematol. 2010;2010:131895.|[2]Bantia S, et al. Purine nucleoside phosphorylase inhibitor BCX-1777 (Immucillin-H)–a novel potent and orally active immunosuppressive agent. Int Immunopharmacol. 2001 Jun;1(6):1199-210.
CAS Number
– 284490-13-7
Molecular Weight
– 302.7142
Compound Purity
– 99.86
SMILES
– O=C1C(NC=C2[C@@H]3N[C@H](CO)[C@@H](O)[C@H]3O)=C2NC=N1.Cl
Clinical Information
– Launched
Research Area
– Cancer
Solubility
– DMSO : 10 mg/mL (ultrasonic)|H2O : 100 mg/mL (ultrasonic)
Target
– Apoptosis;Nucleoside Antimetabolite/Analog
Pathway
– Apoptosis;Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
