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Folinic acid (calcium salt pentahydrate)
$50 – $99
Products Details
Product Description
– Folinic acid calcium salt pentahydrate (Leucovorin calcium salt pentahydrate) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity[1].
Web ID
– HY-B0080
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture and light)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C20H31CaN7O12
Citations
– J Mol Med (Berl). 2019 Aug;97(8):1183-1193.|bioRxiv. 2023 Feb 28.|JAMA Oncol. 2022 Jan 1;8(1):e215445.|Mol Oncol. 2020 Nov;14(11):2894-2919.|Virology. 2023 Jun 21.|J Mol Med (Berl). 2019 Aug;97(8):1183-1193.
References
– [1]Keshava C, et al. Inhibition of methotrexate-induced chromosomal damage by folinic acid in V79 cells. Mutat Res. 1998 Feb 2;397(2):221-8.|[2] Iqbal MP, et al. Effect of methotrexate and folinic acid on skeletal growth in mice. Acta Paediatr. 2003 Dec;92(12):1438-44.
CAS Number
– 6035-45-6
Molecular Weight
– 601.58
Compound Purity
– 98.0
SMILES
– O=CN1C(C2=O)=C(NC(N)=N2)NCC1CNC3=CC=C(C(N[C@H](C([O-])=O)CCC([O-])=O)=O)C=C3.O.O.O.O.[Ca+2].O
Clinical Information
– Launched
Research Area
– Cancer
Solubility
– DMSO : 1 mg/mL (ultrasonic;warming;heat to 80°C)|H2O : 10 mg/mL (ultrasonic)
Target
– Antifolate;Endogenous Metabolite
Isoform
– Human Endogenous Metabolite
Pathway
– Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
