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Fmoc-Ala-Glu-Asn-Lys-NH2
$135 – $235
Products Details
Product Description
– Fmoc-Ala-Glu-Asn-Lys-NH2 is a selective asparagine endopeptidase (AEP) inhibitor peptide and suppresses amyloid precursor protein (APP) cleavage. AEP, a pH-controlled cysteine proteinase, is activated during ageing and mediates APP proteolytic processing[1].
Web ID
– HY-114174
Storage Temperature
– -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Shipping
– Blue Ice
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C33H43N7O9
References
– [1]Zhang Z, et al. Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer’s disease. Nat Commun. 2015;6:8762. Published 2015 Nov 9.|[2]Chen G, et al. Netrin-1 receptor UNC5C cleavage by active δ-secretase enhances neurodegeneration, promoting Alzheimer’s disease pathologies. Sci Adv. 2021 Apr 16;7(16):eabe4499.
CAS Number
– 220701-06-4
Molecular Weight
– 681.74
Compound Purity
– 99.62
SMILES
– NCCCC[C@@H](C(N)=O)NC([C@H](CC(N)=O)NC([C@H](CCC(O)=O)NC([C@H](C)NC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)=O)=O)=O
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– DMSO : 100 mg/mL (ultrasonic;warming;heat to 80°C)|H2O : ≥ 10 mg/mL
Target
– Amyloid-β
Pathway
– Neuronal Signaling
Product type
– Peptides
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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