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Products Details
Product Description
– FLT3/TrKA-IN-1 is a potent FLT3/TrKA dual kinase inhibitor with the IC50s of 43.8 nM, 97.2 nM, 92.5 nM and 23.6 nM for FLT3, FLT3-ITD, FLT3-TKD and TrKA, respectively. FLT3/TrKA-IN-1 induces cell cycle arrest at the G0/G1 phase as well as apoptosis and shows antiproliferative activity in vitro. FLT3/TrKA-IN-1 has the potential for the research of Acute myeloid leukemia (AML)[1].
Web ID
– HY-146749
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C28H30N4O2
References
– [1]Dokla EME, et al. Discovery of a benzimidazole-based dual FLT3/TrKA inhibitor targeting acute myeloid leukemia. Bioorg Med Chem. 2022; 56:116596.
Molecular Weight
– 454.56
SMILES
– CC(NC1=CC=C(C=C1)N2C=NC3=CC(C4=CC=C(C=C4)OCCN5CCCCC5)=CC=C32)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;FLT3;Trk Receptor
Isoform
– TrkA
Pathway
– Apoptosis;Neuronal Signaling;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
