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Products Details
Product Description
– FLT3-IN-15 is a highly potent and orally active FLT3 inhibitor with IC50s of 0.87 nM and 0.32 nM for FLT3 and FLT3/D835Y, respectively. FLT3-IN-15 can be used for researching acute myeloid leukemia[1].
Web ID
– HY-146886
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C22H23ClFN5O2
References
– [1]Jeong P, Moon Y, Lee JH, et al. Discovery of orally active indirubin-3′-oxime derivatives as potent type 1 FLT3 inhibitors for acute myeloid leukemia. Eur J Med Chem. 2020;195:112205.
CAS Number
– 2435562-99-3
Molecular Weight
– 443.90
SMILES
– O=C1NC2=C(/C1=C3NC4=CC=CC=C4C/3=NOCCN5CCNCC5)C=C(C=C2)F.Cl
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– FLT3
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
