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Products Details
Product Description
– FLT3-IN-14 is a potent FLT3 inhibitor with IC50s of 5.6 nM and 1.4 nM for FLT3-WT and FLT3-ITD. FLT3-IN-14 reduces the phosphorylation of FLT3 (Y591), induces cell cycle arrest at G1 phase and apoptosis. FLT3-IN-14 significantly reduces the tumor growth in an MV4-11 xenograft mouse model[1].
Web ID
– HY-144777
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C25H24N6O2S
References
– [1]Cilibrasi V, Spanò V, Bortolozzi R, et al. Synthesis of 2H-Imidazo[2′,1′:2,3] [1,3]thiazolo[4,5-e]isoindol-8-yl-phenylureas with promising therapeutic features for the treatment of acute myeloid leukemia (AML) with FLT3/ITD mutations. Eur J Med Chem. 2022;235:114292.
CAS Number
– 2620551-45-1
Molecular Weight
– 472.56
SMILES
– CC(C)(C1=CC(NC(NC2=CC=C(C=C2)C3=CN4C5=C(SC4=N3)CCC6=CNC=C65)=O)=NO1)C
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;FLT3
Pathway
– Apoptosis;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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