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Products Details
Product Description
– FLT3/D835Y-IN-1 (compound 13a) is a orally active, potent and selective FLT3 and FLT3/D835Y inhibitor, with IC50 values of 0.26 nM and 0.18 nM, respectively. FLT3/D835Y-IN-1 also blocks tumor growth, has anticancer efficacy, and can be used to research for AML (acute myeloid leukemia)[1].
Web ID
– HY-143434
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C22H21N5O3
References
– [1]Lee JH, Shin JE, Kim W, et al. Discovery of indirubin-3′-aminooxy-acetamide derivatives as potent and selective FLT3/D835Y mutant kinase inhibitors for acute myeloid leukemia. Eur J Med Chem. 2022 Apr 21;237:114356.
CAS Number
– 2648799-49-7
Molecular Weight
– 403.43
SMILES
– O=C1NC2=C(C=CC=C2)/C1=C3NC4=C(C=CC=C4)C/3=NOCC(N5CCNCC5)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– FLT3
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
