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Flavopiridol
$66 – $475
Products Details
Product Description
– Flavopiridol (Alvocidib) is a broad spectrum and competitive inhibitor of CDKs, inhibiting CDK1, CDK2, CDK4 with IC50s of 30, 170, 100 nM, respectively.
Web ID
– HY-10005
Storage Temperature
– 4°C (Powder, stored under nitrogen)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C21H20ClNO5
Citations
– ACS Chem Biol. 2017 May 19;12(5):1245-1256.|Acta Pharm Sin B. 26 February 2022.|Biochem Biophys Res Commun. 2019 Jun 11;513(4):967-973.|Biomaterials. 2014 Aug;35(24):6585-94. |bioRxiv. 2023 Sep 7.|Cancers (Basel). 2022 Mar 19;14(6):1575.|Cell Chem Biol. 2018 Feb 15;25(2):135-142.e5.|Cell Chem Biol. 2019 Aug 15;26(8):1067-1080.e8. |Cell Mol Life Sci. 2020 May 21.|Cell Rep. 2020 Apr 28;31(4):107586.|Cell Syst. 2018 Apr 25;6(4):424-443.e7.|Cell. 2021 Apr 15;184(8):2167-2182.e22.|Clin Cancer Res. 2020 Apr 15;26(8):2011-2021. |EMBO Rep. 2022 Apr 11;e53932.|Free University of Berlin. Gedruckt mit Genehmigung des Fachbereichs Veterinärmedizin. 2021 Mar.|Harvard Medical School LINCS LIBRARY|Int J Biol Sci. 2023 Aug 6;19(13):4123-4138.|J Med Chem. 2021 Mar 11;64(5):2725-2738.|Molecules. 2023 Mar 4.|Purdue University. Department of Chemistry.|Research Square Preprint. 2022 Jan.|School of Medicine, Department of Pharmacology. 2020 Jun.|Sci Rep. 2015 Dec 1;5:17675. |Sci Rep. 2021 Mar 8;11(1):5374.|Sci Transl Med. 2018 Jul 18;10(450):eaaq1093.|The University of Chicago. Biological Sciences Division Pritzker School of Medicine. 2022 Aug.|Turk Neurosurg. 2016;26(6):922-929.|Cancer Discov. 2021 Oct 6;candisc.1848.2020.|Cell Commun Signal. 2022 Sep 5;20(1):96.|Proc Natl Acad Sci U S A. 2021 Nov 16;118(46):e2115667118.
References
– [1]Kim KS, et al.Thio- and oxoflavopiridols, cyclin-dependent kinase 1-selective inhibitors: synthesis and biological effects. J Med Chem. 2000 Nov 2;43(22):4126-34.|[2]Mahoney E, et al. ER stress and autophagy: new discoveries in the mechanism of action and drug resistance of the cyclin-dependent kinase inhibitor flavopiridol.Blood. 2012 Aug 9;120(6):1262-1273.|[3]Keskin H, et al. Complex effects of flavopiridol on the expression of primary response genes. Cell Div. 2012 Mar 29;7:11.|[4]Jianliang Xu, et al. Inhibition of cyclin E1 sensitizes hepatocellular carcinoma cells to regorafenib by mcl-1 suppression. Cell Commun Signal. 2019 Jul 26;17(1):85.
CAS Number
– 146426-40-6
Molecular Weight
– 401.84
Compound Purity
– 99.72
SMILES
– O=C1C2=C(C=C(C([C@]3([H])[C@H](O)CN(C)CC3)=C2OC(C4=CC=CC=C4Cl)=C1)O)O
Clinical Information
– Phase 2
Research Area
– Cancer
Solubility
– DMSO : 33.33 mg/mL (ultrasonic)
Target
– Apoptosis;Autophagy;CDK;HIV
Isoform
– CDK1;CDK2;CDK4
Pathway
– Anti-infection;Apoptosis;Autophagy;Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
