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FK888
$566 – $905
Products Details
Product Description
– FK888 is a potent, selective, and high affinity dipeptide NK1 receptor antagonist. FK888 displaces [3H]-SP binding with a Ki value of 0.69 nM and 0.45 microM. FK888 also inhibits SP-induced airway oedema in guinea-pig after both intravenous and oral administration[1].
Web ID
– HY-105215
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C36H36N4O4
References
– [1]Fujii T, et al. Pharmacological profile of a high affinity dipeptide NK1 receptor antagonist, FK888. Br J Pharmacol. 1992;107(3):785-789.
CAS Number
– 138449-07-7
Molecular Weight
– 588.70
SMILES
– O=C(N(C[C@@H]1O)[C@@H](C1)C(N[C@H](C(N(C)CC2=CC=CC=C2)=O)CC3=CC(C=CC=C4)=C4C=C3)=O)C(C5=CC=CC=C56)=CN6C
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Neurokinin Receptor
Isoform
– NK1
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
