FK888

$566$905

Products Details

Product Description

– FK888 is a potent, selective, and high affinity dipeptide NK1 receptor antagonist. FK888 displaces [3H]-SP binding with a Ki value of 0.69 nM and 0.45 microM. FK888 also inhibits SP-induced airway oedema in guinea-pig after both intravenous and oral administration[1].

Web ID

– HY-105215

Shipping

– Room temperature

Applications

– COVID-19-immunoregulation

Molecular Formula

– C36H36N4O4

References

– [1]Fujii T, et al. Pharmacological profile of a high affinity dipeptide NK1 receptor antagonist, FK888. Br J Pharmacol. 1992;107(3):785-789.

CAS Number

– 138449-07-7

Molecular Weight

– 588.70

SMILES

– O=C(N(C[C@@H]1O)[C@@H](C1)C(N[C@H](C(N(C)CC2=CC=CC=C2)=O)CC3=CC(C=CC=C4)=C4C=C3)=O)C(C5=CC=CC=C56)=CN6C

Clinical Information

– No Development Reported

Research Area

– Inflammation/Immunology

Solubility

– 10 mM in DMSO

Target

– Neurokinin Receptor

Isoform

– NK1

Pathway

– GPCR/G Protein;Neuronal Signaling

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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