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Fitusiran
$750 – $3,590
Products Details
Product Description
– Fitusiran (ALN-AT3SC), an small interfering RNA, specifically targets antithrombin (AT) messenger RNA to lower production of AT in the liver. Fitusiran increases thrombin generation and has the potential for the research of the hemophilia[1].
Web ID
– HY-132587
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C520H679F21N175O309P43S6
References
– [1]Pasi KJ, et al. Targeting of antithrombin in hemophilia A or B with investigational siRNA therapeutic fitusiran-Results of the phase 1 inhibitor cohort. J Thromb Haemost. 2021;19(6):1436-1446.
CAS Number
– 1499251-18-1
Molecular Weight
– 16248.2 (AS: 7675 + SS: 8573.2)
Compound Purity
– 94.68
SMILES
– [Fitusiran]
Clinical Information
– Phase 3
Research Area
– Others
Solubility
– H2O : 50 mg/mL (ultrasonic)
Target
– Factor Xa;Small Interfering RNA (siRNA)
Pathway
– Epigenetics;Metabolic Enzyme/Protease
Product type
– Oligonucleotides
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
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