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Filorexant
$180 – $1,176
Products Details
Product Description
– Filorexant (MK-6096) is an orally bioavailable potent and selective reversible antagonist of OX1 and OX2 receptor(<3 nM in binding).
Web ID
– HY-15653
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C24H25FN4O2
References
– [1]Winrow CJ, et al. Pharmacological characterization of MK-6096 – a dual orexin receptor antagonist for insomnia. Neuropharmacology. 2012 Feb;62(2):978-87.|[2]Coleman PJ, et al. Discovery of [(2R,5R)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): a dual orexin receptor antagonist with potent sleep-promoting properties. ChemMedChem. 2012 Mar 5;7(3):415-24, 337.
CAS Number
– 1088991-73-4
Molecular Weight
– 420.48
Compound Purity
– 99.35
SMILES
– CC1=CC(C(N2C[C@H](COC3=CC=C(F)C=N3)CC[C@H]2C)=O)=C(C4=NC=CC=N4)C=C1
Clinical Information
– Phase 2
Research Area
– Neurological Disease; Endocrinology
Solubility
– DMSO : 100 mg/mL (ultrasonic)
Target
– Orexin Receptor (OX Receptor)
Isoform
– OX2 Receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
