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FICZ
$60 – $600
Products Details
Product Description
– FICZ is a potent aryl hydrocarbon receptor (AhR) agonist with a Kd of 70 pM.
Web ID
– HY-12451
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Molecular Formula
– C19H12N2O
References
– [1]Riccardo Sibilano, et al. The Aryl Hydrocarbon Receptor Modulates Acute and Late Mast Cell Responses. J Immunol. 2012 Jul 1;189(1):120-7.|[2]N A Davarinos, et al. Aryl Hydrocarbon Receptor Imported Into the Nucleus Following Ligand Binding Is Rapidly Degraded via the Cytosplasmic Proteasome Following Nuclear Export. J Biol Chem. 1999 Oct 1;274(40):28708-15.|[3]Smith BW, et al. Genome Editing of the CYP1A1 Locus in iPSCs as a Platform to Map AHR Expression throughout Human Development. Stem Cells Int. 2016;2016:2574152.|[4]Mohammadi-Bardbori A, et al. The highly bioactive molecule and signal substance 6-formylindolo[3,2-b]carbazole (FICZ) plays bi-functional roles in cell growth and apoptosis in vitro. Arch Toxicol. 2017 Mar 13|[5]Farmahin R, et al. Time-dependent transcriptomic and biochemical responses of 6-formylindolo[3,2-b]carbazole (FICZ) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are explained by AHR activation time. Biochem Pharmacol. 2016 Sep 1;115:134-43|[6]Wincent E, et al. Biological effects of 6-formylindolo[3,2-b]carbazole (FICZ) in vivo are enhanced by loss of CYP1A function in an Ahr2-dependent manner. Biochem Pharmacol. 2016 Jun 15;110-111:117-29.
CAS Number
– 172922-91-7
Molecular Weight
– 284.31
Compound Purity
– 99.42
SMILES
– O=CC1=C2C(NC3=C2C=CC=C3)=CC4=C1NC5=C4C=CC=C5
Clinical Information
– No Development Reported
Research Area
– Others
Solubility
– DMSO : 10 mg/mL (ultrasonic;warming)
Target
– Aryl Hydrocarbon Receptor
Pathway
– Immunology/Inflammation
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
