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Products Details
Product Description
– FGFR3-IN-2 (compound 18b) is a potent and selective FGFR3 inhibitor, with IC50s of 4.1 nM and 570 nM for FGFR3 and VEGFR2, respectively. FGFR3-IN-2 can be used for the research of bladder cancer[1].
Web ID
– HY-147714
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C28H39N9O4S
References
– [1]Kuriwaki I, et, al. Structure-based drug design of 1,3,5-triazine and pyrimidine derivatives as novel FGFR3 inhibitors with high selectivity over VEGFR2. Bioorg Med Chem. 2020 May 15;28(10):115453.
CAS Number
– 2428742-58-7
Molecular Weight
– 597.73
SMILES
– CCNS(=O)(C1=CC=CC=C1NC2=NC(NC3=CC=C(C(OCCN4CCOCC4)=C3)N5CCN(CC5)C)=NC=N2)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– FGFR;VEGFR
Isoform
– FGFR3;VEGFR2/KDR/Flk-1
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
