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Products Details
Product Description
– FGFR1 inhibitor-6 is a potent FGFR1 inhibitor with an IC50 value of 16.31 nM. FGFR1 inhibitor-6 shows cytotoxic activities. FGFR1 inhibitor-6 induces apoptosis and cell cycle arrest at pre-G1 and G2/M phase[1].
Web ID
– HY-143272
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C27H19N5O4S2
References
– [1]Abd El-Meguid EA, et al. Synthesis, anticancer evaluation and molecular docking of new benzothiazole scaffolds targeting FGFR-1. Bioorg Chem. 2022 Feb;119:105504.
Molecular Weight
– 541.60
SMILES
– COC1=CC(C2=NC3=CC=CC=C3S2)=CC=C1OCC(N/N=C4NC(/C(S/4)=C/C5=CC=C(C=C5)C#N)=O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– FGFR
Isoform
– FGFR1
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
