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Fexofenadine (hydrochloride)
$35 – $220
Products Details
Product Description
– Fexofenadine (MDL-16455) hydrochloride is an orally active and nonsedative H1 receptor antagonist. Fexofenadine hydrochloride can be used in allergic rhinitis and chronic idiopathic urticarial research[1][2][3].
Web ID
– HY-B0801A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C32H40ClNO4
Citations
– Int Immunopharmacol. 2023 Feb 8;116:109637.|Adv Mater Technol. 2023 Jan 29.|Pharmacol Res. 2023 Mar 10;106724.
References
– [1]Watanabe N, et al. The effects of fexofenadine on eosinophilia and systemic anaphylaxis in mice infected with Trichinella spiralis. Int Immunopharmacol. 2004 Mar;4(3):367-75.|[2]Park IH, et al. Histamine Promotes the Release of Interleukin-6 via the H1R/p38 and NF-κB Pathways in Nasal Fibroblasts. Allergy Asthma Immunol Res. 2014 Nov;6(6):567-72.|[3]Ming X, et al. Vectorial transport of fexofenadine across Caco-2 cells: involvement of apical uptake and basolateral efflux transporters. Mol Pharm. 2011 Oct 3;8(5):1677-86.
CAS Number
– 153439-40-8
Molecular Weight
– 538.12
Compound Purity
– 99.86
SMILES
– O=C(O)C(C)(C)C1=CC=C(C(O)CCCN2CCC(C(C3=CC=CC=C3)(O)C4=CC=CC=C4)CC2)C=C1.[H]Cl
Clinical Information
– Launched
Research Area
– Inflammation/Immunology
Solubility
– DMSO : ≥ 100 mg/mL|H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– Histamine Receptor
Isoform
– H1 Receptor
Pathway
– GPCR/G Protein;Immunology/Inflammation;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
