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Fevipiprant
SKU
HY-16768-10 mg
Category Reference compound
Tags Cardiovascular Disease, CRTH2 (GPR44);Prostaglandin Receptor, GPCR/G Protein;Immunology/Inflammation
$60 – $450
Products Details
Product Description
– Fevipiprant (QAW039, NVP-QAW039) is s an orally active, selective, reversible prostaglandin D2 (DP2) receptor antagonist with an Kd value of 1.14 nM. Fevipiprant has the potential for the research of bronchial asthma[1][2][3].
Web ID
– HY-16768
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C19H17F3N2O4S
References
– [1]Brightling C, et al. The pharmacology of the prostaglandin D2 receptor 2 (DP2) receptor antagonist, fevipiprant. Pulm Pharmacol Ther. 2021 Jun;68:102030.|[2]Lee HY, et al. Blockade of thymic stromal lymphopoietin and CRTH2 attenuates airway inflammation in a murine model of allergic asthma. Korean J Intern Med. 2020 May;35(3):619-629. |[3]Weintraub NL, et al. Role of prostaglandin D2 receptors in the pathogenesis of abdominal aortic aneurysm formation. Clin Sci (Lond). 2022 Mar 18;136(5):309-321.
CAS Number
– 872365-14-5
Molecular Weight
– 426.41
Compound Purity
– 99.63
SMILES
– O=C(O)CC1=C(C)N(CC2=CC=C(S(=O)(C)=O)C=C2C(F)(F)F)C3=NC=CC=C31
Clinical Information
– Phase 3
Research Area
– Cardiovascular Disease
Solubility
– DMSO : ≥ 32 mg/mL
Target
– CRTH2 (GPR44);Prostaglandin Receptor
Isoform
– DP
Pathway
– GPCR/G Protein;Immunology/Inflammation
Product type
– Reference compound
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