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Fenoldopam (mesylate)
$35 – $286
Products Details
Product Description
– Fenoldopam mesylate (SKF-82526) is a D1 receptor agonist and a novel lysine-specific demethylase 1 (LSD1) inhibitor (IC50=0.8974 μM). Fenoldopam mesylate shows anti-hypertensive effects, anti-cancer cell proliferation activity and can induce cells apoptosis[1][2][3].
Web ID
– HY-B0735A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C17H20ClNO6S
Citations
– Cell. 2021 Feb 18;184(4):943-956.e18.|Biochem Biophys Res Commun. 18 December 2021.|Biomed Pharmacother. 2021, 111500.|SLAS Discov. 2020 Sep;25(8):895-905.
References
– [1]A Grenader, et al. Fenoldopam is a partial agonist at dopamine-1 (DA1) receptors in LLC-PK1 cells. J Pharmacol Exp Ther. 1991 Jul 1;258(1):193-8.|[2]Yan Zheng, et al. Identification of fenoldopam as a novel LSD1 inhibitor to abrogate the proliferation of renal cell carcinoma using drug repurposing strategy. Bioorg Chem. 2021 Mar;108:104561.|[3]Yuta Fujii, et al. Detection of fenoldopam-induced arteritis in rats using ex vivo / in vivo MRI. Toxicology Reports, Volume 9, 2022, Pages 1595-1602.
CAS Number
– 67227-57-0
Molecular Weight
– 401.86
Compound Purity
– 99.94
SMILES
– OC1=C(O)C=C2C(C3=CC=C(O)C=C3)CNCCC2=C1Cl.CS(=O)(O)=O
Clinical Information
– Launched
Research Area
– Cancer; Cardiovascular Disease
Solubility
– DMSO : ≥ 36 mg/mL|H2O : 10 mg/mL (ultrasonic)
Target
– Apoptosis;Dopamine Receptor
Pathway
– Apoptosis;GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
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